Meng, Shan-Shui; Tang, Xiaowen; Luo, Xiang; Wu, Ruibo; Zhao, Jun-Ling; Chan, Albert S. C. published the artcile< Borane-Catalyzed Chemoselectivity-Controllable N-Alkylation and ortho C-Alkylation of Unprotected Arylamines Using Benzylic Alcohols>, Computed Properties of 76-84-6, the main research area is borane catalyzed chemoselectivity controllable nitrogen ortho carbon alkylation; alkylation unprotected arylamine benzylic alc DFT calculation.
An unprecedented protocol for the efficient and highly chemoselective alkylation of unprotected arylamines using alcs. catalyzed by B(C6F5)3 has been developed. The reaction gives N-alkylated products and ortho C-alkylated products in different solvents in good chemoselectivities and yields. Control experiments and DFT calculations indicated that the borane underwent alc./arylamine exchange to ensure catalytic activity, and a possible mechanism involving a carbocation is proposed.
ACS Catalysis published new progress about Alkylation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts