The author of 《Concise and efficient syntheses of methyl 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine》 were Ma, Xiao-Yan; Huang, Jian-Ping; Yang, Jing; Liu, Xingyong; Hu, Xinjun; Huang, Sheng-Xiong. And the article was published in Canadian Journal of Chemistry in 2020. Safety of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:
Me 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine are important biosynthetic intermediates for tropane alkaloids. A concise method to synthesize these two compounds from the key intermediate N-methylpyrrolinium cation has been developed. Me 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine were obtained in four and six steps from com. available 4,4-diethoxybutylamine with overall yields of 42% and 25%, resp. In the experiment, the researchers used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Safety of 4,4-Diethoxybutan-1-amine)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Safety of 4,4-Diethoxybutan-1-amine
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