Liu, Yiyun; Xi, Yixin; Zhao, Jiulong; Zhao, Jiayan; Li, Jincan; Huang, Guoqi; Li, Junqiang; Fang, Fei; Gu, Lingling; Wang, Shige published the artcile< Preparation of therapeutic-laden konjac hydrogel for tumor combination therapy>, Related Products of 1492-18-8, the main research area is therapeutic laden konjac hydrogel tumor combination therapy.
Featured with three-dimensional network structure, polymer hydrogels have found tremendous applications in biomedical fields. In this study, therapeutic-laden Konjac glucomannan (KGM) hydrogel was prepared by injecting polydopamine (PDA)/5-fluorouracil (5-FU)/calcium folinate (CF)/KGM alk. solution to the target area, for the synergistic tumor photothermal and chemotherapy. In alk. solution, dopamine can be synchronously polymerized to form PDA, while KGM can be hydrolyzed and transformed into a thermally irreversible KGM hydrogel. Besides, the alk. condition can increase the solubility of 5-FU. The hydrogel matrix can control the release of 5-FU and cf. PDA renders the composite hydrogel excellent tumor photothermal therapy ability. Moreover, CF can be used as a synergist to enhance the tumor chemotherapy efficiency of 5-FU. With convenient handling, excellent photothermal conversion ability and high biocompatibility, the multifunctional hydrogel system is anticipated to find a promising translational potential in clin. therapeutic applications.
Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts