In 2017,Li, Zhao; Tamura, Masamichi; Yazaki, Ryo; Ohshima, Takashi published 《Catalytic chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester: hydroxy group over amino group and conjugate addition over transesterification》.Chemical & Pharmaceutical Bulletin published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:
A highly chemoselective conjugate addition of amino alcs. to α,β-unsaturated ester using a soft Lewis acid/hard Bronsted base cooperative catalyst was developed. This catalysis achieved chemoselective addition of a hydroxy group over an amino group. Moreover, soft metal alkoxide generation enabled chemoselective soft conjugate addition over hard transesterification. Various amino alcs., including unprecedented cyclic β-amino alc., were applicable to the present catalysis. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts