The author of 《Synthesis, structure activity relationship and anti-influenza A virus evaluation of oleanolic acid-linear amino derivatives》 were Li, Weijia; Yang, Fan; Meng, Lingkuan; Sun, Jiaqi; Su, Yangqing; Shao, Liang; Zhou, Demin; Yu, Fei. And the article was published in Chemical & Pharmaceutical Bulletin in 2019. Product Details of 4048-33-3 The author mentioned the following in the article:
Olcanolic acid (OA) was discovered as a mild influenza hemagglutinin (HA) inhibitor in our earlier studies. In the present work, 20 compounds were prepared by structural modifications of OA, and their anti-viral activities against influenza A/WSN/33 (H1N1) virus in Madin-Darby canine kidney (MDCK) cells were evaluated. Based on the biol. result, structure-activity relationship (SAR) was discussed. Compound 10 with six-carbon chain and a terminal hydroxyl group showed the strongest anti-influenza activity with an IC50 of 2.98μM, which is an order of magnitude more potent than OA. Hemagglutination inhibition and Surface plasmon resonance (SPR) assay indicated that compound 10 might interfere with influenza invasion by interacting with HA protein. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3Product Details of 4048-33-3)
6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Product Details of 4048-33-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts