Li, Sifan; Wang, Yu; Wu, Zibo; Shi, Weiliang; Lei, Yibo; Davies, Paul W.; Shu, Wei published the artcile< A Radical-Initiated Fragmentary Rearrangement Cascade of Ene-Ynamides to [1,2]-Annulated Indoles via Site-Selective Cyclization>, Name: But-3-en-1-ol, the main research area is annulated indole regioselective preparation; ene ynamide fragmentary rearrangement cascade radical initiated.
Herein, a radical triggered fragmentary cyclization cascade reaction of ene-ynamides was presented, providing a rapid access into [1,2]-annulated indoles I [R = H, Me, SMe, etc.; R1 = Ph, 4-MeC6H4, 3-pyridyl, etc.; R2 = H, Me, n-Bu; n = 1,2,3] by an intermol. radical addition, intramol. cyclization, desulfonylative aryl migration, and site-selective C(sp2)-N cyclization sequence. DFT calculations support oxidation of N-centered radical species to cations prior to the C-N bond formation, followed by an unusual aza-Nazarov cyclization.
Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts