Leal, Angela C. G. B.; Correa, Marcelo P.; Holick, Michael F.; Melo, Enaldo V.; Lazaretti-Castro, Marise published the artcile< Sun-induced production of vitamin D3 throughout 1 year in tropical and subtropical regions: relationship with latitude, cloudiness, UV-B exposure and solar zenith angle>, SDS of cas: 434-16-2, the main research area is cholecalciferol sun tropical subtropical region latitude UVBexposure zenithangle; Latitude; Photoconversion; Solar zenith angle; Sunlight; UV-B; Vitamin D.
This study evaluated the differences in vitamin D3 synthesis in two different latitudes throughout 1 yr using an in vitro model, which simulates cutaneous vitamin D photoproduction Borosilicate ampoules containing 7-dehydrocholesterol (7-DHC) were exposed to sunlight hourly throughout the daylight hours, 1 day per mo for a year, in Fortaleza (latitude 03° 43′ 01″” S-LAT3° S) and Sao Paulo (latitude 23° 32′ 53″” S-LAT23° S). Later, vitamin D3 and photoisomers of 7-DHC (tachysterol and lumisterol) were measured by a high-performance liquid chromatog. system (HPLC). Vitamin D synthesis weighted UV radiation (UVBVitD) and solar zenith angle (SZA) were calculated during the same periods for both latitudes. Vitamin D3 synthesis occurred throughout the year in both locations, as expected in latitudes lower than 35°. Median of photoconversion to vitamin D3 through the year was higher in LAT3°S [median (IQR): LAT 3°S 4.1% (6.0); LAT 23°S 2.9% (4.5); p value = 0.020]. Vitamin D3 production strongly correlated with UV-B (LAT3° S, r = 0.917; p < 0.0001 and at LAT23° S, r = 0.879; p < 0.0001) and SZA (LAT3° S, r = - 0.924; p < 0.0001 and in LAT23°S, r = - 0.808; p < 0.0001). Vitamin D3 production starts later in LAT23° S, especially in winter. Lowest percentages were observed in June in both cities, although, compared to LAT3° S, in LAT 23° S the conversion was over 50% lower in the winter period. Cloudiness impaired photoproduction of Vitamin D3 even in summer months in both latitudes. Our results provide data to help guide medical recommendations for sensible sun exposure to promote the cutaneous production of vitamin D3 at different latitudes, seasonality, time of day and cloudiness status in Brazil. Photochemical & Photobiological Sciences published new progress about Ampuls. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.
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