《Quantitative structure activity relationships of catechol derivatives on nerve growth factor secretion in L-M cells》 was written by Kourounakis, Angeliki; Bodor, Nicholas. Electric Literature of C10H14O2 And the article was included in Pharmaceutical Research on August 31 ,1995. The article conveys some information:
Although many catechol derivatives are potent stimulators of Nerve Growth Factor synthesis in L-M cells, not much is known about their mechanism of action. In order to obtain a Quant. Structure Activity Relationship (QSAR), AM1 quantum mech. calculations were performed on a group of 23 catechol derivatives with different levels of activity. A set of 18 parameters/descriptors were obtained by AM1 quantum mech. calculations for each catechol derivative Linear combinations of the calculated descriptors were fitted to the activity (as extracted from literature data) of the compounds by using simple or multiple regression anal. The results show that activity is associated with parameters related to the oxidation of the catechol derivatives, strongly supporting recent literature suggesting that an oxidative process is involved in their action. After reading the article, we found that the author used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Electric Literature of C10H14O2)
4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Electric Literature of C10H14O2
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