Kim, Seon Woong; Lee, Taeho; Lee, Joo-Youn; Kim, Sanghee; Jun, Hee-Sook; Park, Eun-Young; Baek, Dong Jae published the artcile< Synthesis and Biological Evaluation of PF-543 Derivative>, Related Products of 10602-04-7, the main research area is phenylsulfonylmethylphenethyl benzylpyrrolidinyl methanol preparation antitumor mol docking sphingosine kinase.
Compared PF-543 I and synthesized a newly designed derivative of PF-543 II in which two aromatic structures were connected in para-form. The synthesized derivative II showed inhibitory effect on SK1, similar to that of PF-543 I. However, it was more cytotoxic to HT29, AGS, and PC3 cells than PF-543 I. Also carried out a docking study for SK1 and demonstrated that the synthesized derivative II showed interaction with SK1 similar to PF-543 I. Results obtained from this study suggest that the structure of II may be well substituted for the structure of PF-543 I in terms of biol. activity, providing important structural information for the design of new derivatives of PF-543 II.
Letters in Organic Chemistry published new progress about Antitumor agents. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Related Products of 10602-04-7.
Referemce:
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Alcohols – Chemistry LibreTexts