《Asymmetric Total Synthesis of Inthomycins A, B, and C》 was published in Journal of Organic Chemistry in 2020. These research results belong to Kim, Jae Hyun; Song, Yeonghun; Kim, Min Jung; Kim, Sanghee. Application In Synthesis of Bis[(pinacolato)boryl]methane The article mentions the following:
Herein, we report the asym. total syntheses of inthomycin antibiotics containing a methylene-interrupted oxazolyl-triene motif. Utilizing the α,β-unsaturated aldehyde as a common intermediate, all three inthomycins A-C were divergently synthesized. The asym. ynone reduction provided an R-configured secondary alc. as in the natural products with high enantioselectivity. The geometrically different triene units for each inthomycin were stereoselectively established via Me cuprate conjugate addition, isomerization of the α,β-unsaturated aldehyde intermediate, and stereoretentive cross-coupling reactions. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Application In Synthesis of Bis[(pinacolato)boryl]methane)
Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Application In Synthesis of Bis[(pinacolato)boryl]methane Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.
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