HPLC of Formula: 63012-03-3On November 5, 2004 ,《The effects of aromatic substituents on the chromatographic enantioseparation of diarylmethyl esters with the Whelk-O1 chiral stationary phase》 appeared in Journal of Chromatography A. The author of the article were Job, Gabriel E.; Shvets, Alex; Pirkle, William H.; Kuwahara, Shunsuke; Kosaka, Masashi; Kasai, Yusuke; Taji, Hiromi; Fujita, Kaori; Watanabe, Masataka; Harada, Nobuyuki. The article conveys some information:
Members of diarylmethanols, diarylmethyl pivalates, and diarylmethyl acetates were enantioresolved with the (S,S)-Whelk-O1 chiral stationary phase (CSP). An analog of the (S,S)-Whelk-O1 selector was combined with enantioenriched samples of the various diarylmethyl pivalates and thereby used as a chiral solvating agent (CSA) for high field 1H NMR studies. The absolute configurations of a number of chiral diarylmethyl pivalates were assigned using this approach, and hydrolysis of the pivalates allowed assignment of the absolute configurations of the corresponding diarylmethanols. Chromatog., 1H NMR, and x-ray evidence are given in support of a chiral recognition model for the enantioresoln. of diarylmethyl esters on this CSP. In the experimental materials used by the author, we found (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3HPLC of Formula: 63012-03-3)
(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.HPLC of Formula: 63012-03-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts