《One-Pot Generation of Functionalized Benzynes from Readily Available 2-Hydroxyphenylboronic Acids》 was written by Ikawa, Takashi; Sun, Jing Kai; Takagi, Akira; Akai, Shuji. Related Products of 89466-08-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:
A one-pot method for the generation of benzynes from a range of readily available 2-hydroxyphenylboronic acids 2-OH-3-R-4-R1-5-R2-C6HB(OH)2 (R = H, Me, F; R1 = H, F; R2 = H, F, CN, OCF3, etc.) was developed. This method features the in situ activation of both boronic acid and hydroxyl groups of the substrate to enhance benzyne generation at 60°C. Such mild conditions facilitate the generation of functionalized benzynes that immediately react with diverse arynophiles e.g., 1,3-diphenylisobenzofuran to produce multisubstituted fused benzenes e.g., 9,10-diphenyl-9,10-dihydro-9,10-epoxyanthracene. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0) was used in this study.
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts