In 2018,Huang, Bing-Bing; Wu, Liang; Liu, Ren-Rong; Xing, Ling-Ling; Liang, Ren-Xiao; Jia, Yi-Xia published 《Enantioselective Friedel-Crafts C2-alkylation of 3-substituted indoles with trifluoropyruvates and cyclic N-sulfonyl α-ketiminoesters》.Organic Chemistry Frontiers published the findings.Synthetic Route of C9H11NO The information in the text is summarized as follows:
Enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles I (R1 = H, 5-MeO, 6-F, etc.; R2 = Me, Ph) with trifluoropyruvates F3CC(O)CO2R3 (R3 = Me, Et) and cyclic N-sulfonyl α-ketiminoesters II (R4 = H, 4-Cl, 4,7-F2, 6-Me, etc.; R5 = Me, Et, i-Pr) were developed by using the complexes of Cu(OTf)2 or Zn(OTf)2 with chiral bisoxazoline ligands. A range of chiral indole-containing trifluoromethylated α-hydroxy esters III and cyclic α-amino esters bearing quaternary stereogenic centers IV was prepared, resp., in good yields and with excellent enantioselectivities (up to 99% ee) under mild conditions. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Synthetic Route of C9H11NO
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