Hewitt, Kirsten A.; Xie, Pei-Pei; Thane, Taylor A.; Hirbawi, Nadia; Zhang, Shuo-Qing; Matus, Alissa C.; Lucas, Erika L.; Hong, Xin; Jarvo, Elizabeth R. published the artcile< Nickel-Catalyzed Domino Cross-Electrophile Coupling Dicarbofunctionalization Reaction To Afford Vinylcyclopropanes>, SDS of cas: 627-27-0, the main research area is vinylcyclopropane enantioselective diastereoselective preparation DFT; alkynyl tosylpiperidine domino cross electrophile coupling dicarbofunctionalization nickel catalyst.
A nickel-catalyzed domino reaction was established that harnesses sulfonamide, alkyl chloride, and alkyne functionalities in a multistep sequence to afford vinylcyclopropanes I [R = Me, n-hexyl, Ph, etc.] bearing tetrasubstituted olefins. The starting materials were prepared by iron-promoted aza-Prins reactions of ynals. This method provided rapid synthetic access to valuable building blocks with applications in medicinal chem. Exptl. and computational results supported the initiation of the catalytic cycle by the oxidative addition of propargylic sulfonamide, and a key ambiphilic allenylnickel intermediate leads to a bifurcated reaction pathway that generates olefin isomers.
ACS Catalysis published new progress about Alkenes, trans Role: SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts