The author of 《2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents》 were Haviv, Fortuna; DeNet, Robert W.; Michaels, Raymond J.; Ratajczyk, James D.; Carter, George W.; Young, Patrick R.. And the article was published in Journal of Medicinal Chemistry in 1983. Application of 55218-73-0 The author mentioned the following in the article:
The title compounds I (R = H, Br, Cl, F, Me, NH2, OMe, etc., R1 = H, Cl, OH, Me, OMe, Ph, etc.) and related compounds as the HCl salts, prepared mostly by the reaction of 2-picolyl chloride [4377-33-7] or 2-(hydroxymethyl)pyridine [586-98-1] with the appropriate mercaptol either in 48% HBr under reflux or in the presence of NaOEt in EtOH at room temperature, were investigated as inflammation inhibitors in rat. I (R = H, Br, Cl, F, or NO2 and R1 = H) were effective inhibitors of immune complex induced inflammation as represented by the rat reverse passive Arthus reaction. 2-[[(4-bromophenyl)thio]methyl]pyridine (I; R = Br, R1 = H) [83782-10-9] also inhibited both exudate formation and cellular accumulation in the more conventional carrageenin pleural test, whereas indomethacin inhibited only exudate volume in this model. Structure-activity relations are discussed. The results came from multiple reactions, including the reaction of (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application of 55218-73-0)
(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Application of 55218-73-0
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