《Detection and phase I metabolism of the 7-azaindole-derived synthetic cannabinoid 5F-AB-P7AICA including a preliminary pharmacokinetic evaluation》 was published in Drug Testing and Analysis in 2020. These research results belong to Giorgetti, Arianna; Mogler, Lukas; Haschimi, Belal; Halter, Sebastian; Franz, Florian; Westphal, Folker; Fischmann, Svenja; Riedel, Jan; Putz, Michael; Auwarter, Volker. Recommanded Product: 7748-36-9 The article mentions the following:
In June 2018, a ′research chemica′l labeled ′AB-FUB7AICA′ was purchased online and anal. identified as 5F-AB-P7AICA, the 7-azaindole analog of 5F-AB-PINACA. Here we present data on structural characterization, suitable urinary consumption markers, and preliminary pharmacokinetic data. Structure characterization was performed by NMR spectroscopy, gas chromatog.-mass spectrometry, IR and Raman spectroscopy. Phase I metabolites were generated by applying a pooled human liver microsome assay (pHLM) to confirm the anal. results of authentic urine samples collected after oral self-administration of 2.5 mg 5F-AB-P7AICA. Analyses of pHLM and urine samples were performed by liquid chromatog.-time-of-flight mass spectrometry and liquid chromatog.-tandem mass spectrometry (LC-MS/MS). An LC-MS/MS method for the quantification of 5F-AB-P7AICA in serum was validated. Ten phase I metabolites were detected in human urine samples and confirmed in vitro. The main metabolites were formed by hydroxylation, amide hydrolysis, and hydrolytic defluorination, though – in contrast with most other synthetic cannabinoids – the parent compound showed the highest signals in most urine samples. The compound detection window was more than 45 h in serum. The concentration-time profile was best explained by a two-phase pharmacokinetic model. 5F-AB-P7AICA was detected in urine samples until 65 h post ingestion. Monitoring of metabolite M07, hydroxylated at the alkyl chain, next to parent 5F-AB-P7AICA, is recommended to confirm the uptake of 5F-AB-P7AICA in urinalysis. It seems plausible that the shift of the nitrogen atom from position 2 to 7 (e.g. 5F-AB-PINACA to 5F-AB-P7AICA) leads to a lower metabolic reactivity, which might be of general interest in medicinal chem. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)
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