Garlatti, Laura; Huet, Raphael; Alvarez, Karine published the artcile< Efficient access to 3'-deoxy-3'-(4-substituted-1,2,3-triazol-1-yl)-thymidine derivatives via ligand-promoted CuAAC>, Computed Properties of 10602-04-7, the main research area is click alkyne azide triazole cycloaddition catalyst preparation nucleoside.
Herein we describe an efficient and rapid access to 3′-deoxy-3′-(4-substituted-1,2,3-triazol-1-yl)-thymidine derivatives, e.g. I, using 1,3-dipolar cycloaddition reaction catalyzed by copper(I). Innovative conditions allow us to generate target compounds in a one-pot reaction mixing 3′-azido-3′-deoxythymidine, alkyne, copper sulfate pentahydrate, sodium ascorbate and tris(benzyltriazolylmethyl)amine in a water:tert-butanol solvent mixture Rapid treatment of the reaction and subsequent flash purification chromatog. afforded pure compounds in an overall yield of 71-100%. All eleven synthesized compounds were identified on the basis of their spectral data anal. (1H, 13C, 2D NMR and high-resolution mass spectra).
Tetrahedron published new progress about 1,3-Dipolar cycloaddition reaction. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Computed Properties of 10602-04-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts