Application In Synthesis of 4-Butylbenzene-1,2-diolOn November 15, 1990 ,《Stimulatory effect of 4-alkylcatechols and their diacetylated derivatives on the synthesis of nerve growth factor》 appeared in Biochemical Pharmacology. The author of the article were Furukawa, Yoshiko; Fukazawa, Nobuyuki; Miyama, Yukio; Hayashi, Kyozo; Furukawa, Shoei. The article conveys some information:
A series of 4-alkylcatechols and 1,2-diacetoxy-4-alkylbenzenes (Me to Bu) were synthesized for in vitro evaluation as stimulators of nerve growth factor (NGF) synthesis. All compounds were potent in stimulating NGF synthesis in L-M cells (a mouse fibroblast cell line) and mouse astroglial cells. In a series of 4-alkylcatechols, 4-methylcatechol and 4-ethylcatechol severely affected viability and cell adhesive properties. In a series of 1,2-diacetoxy-4-alkylbenzenes, the concentrations required for the maximal effect and the effective ranges of concentrations were higher than those in the 4-alkylcatechol series, and the cell adhesive properties or viabilities were not affected. Evidence is also presented to indicate that the elevation of NGF synthesis by these compounds was not associated with the cell growth. In addition to this study using 4-Butylbenzene-1,2-diol, there are many other studies that have used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Application In Synthesis of 4-Butylbenzene-1,2-diol) was used in this study.
4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Application In Synthesis of 4-Butylbenzene-1,2-diol
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