Feng, Guanping; Zou, Wenying; Zhong, Yihui published the artcile< Sulfonamides repress cell division in the root apical meristem by inhibiting folates synthesis>, Synthetic Route of 1492-18-8, the main research area is sulfonamide folic acid synthesis cell division root apical meristem.
Sulfonamides, as broad-spectrum antibiotics, are widely used to protect against bacterial infections in livestock production A large number of sulfa antibiotics are discharged into soil and water system, which poses a great threat to the safety of organisms. The antibacterial mechanism of sulfonamides is to prevent folate biosynthesis by competitively inhibiting bacterial dihydropteroate synthetase (DHPS). The inhibitory effect of sulfanilamide on root growth has been reported, but the mechanism has not been determined Here, we used high performance liquid chromatog. with UV detector (HPLC-UV) and transgenic technol. to study the effect of sulfonamides on folate synthesis in plants. The results showed that the application of sulfonamide sharply reduced the content of folic acid in plants, resulting in strong inhibition of cell division in the root apical meristem. The inhibition of sulfonamide on cell division can be relieved by supplementing synthetic folic acid and folinic calcium salt hydrate. The transgenic plants expressing the bacterial antibiotic resistance genes (ARGs) Sul1 or Sul2 showed obvious antibiotic resistance. Taking these results together, we suggest that sulfonamides repress cell proliferation in the root apical meristem by competitively inhibiting the biosynthesis of folic acid in plants.
Journal of Hazardous Materials Advances published new progress about Antibiotic resistance. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Synthetic Route of 1492-18-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts