Dang, Xiawei’s team published research in Journal of Medicinal Chemistry in 2021 | CAS: 27489-62-9

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of trans-4-Aminocyclohexanol

Dang, Xiawei; Williams, Sidney B.; Devanathan, Sriram; Franco, Antonietta; Fu, Lijun; Bernstein, Peter R.; Walters, Daniel; Dorn, Gerald W. II published an article in 2021. The article was titled 《Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity》, and you may find the article in Journal of Medicinal Chemistry.Quality Control of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small mol. mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first-in-class mitofusin activator, 2, has a short plasma t1/2 and limited neurol. system bioavailability, conferring “”burst activation””. Here, pharmacophore-based rational redesign generated analogs of 2 incorporating cycloalkyl linker groups. A cyclopropyl-containing linker, 5, improved plasma and brain t1/2, increased nervous system bioavailability, and prolonged neuron pharmacodynamic effects. Functional and single-crystal X-ray diffraction studies of stereoisomeric analogs of 5 containing sulfur as a “”heavy atom””, 14A and 14B, showed that 5 biol. activity resides in the trans-R/R configuration, 5B. Structural anal. revealed stereoselective interactions of 5 associated with its mimicry of MFN2 Val372, Met376, and His380 side chains. Modification of murine ALS phenotypes in vitro and in vivo supports advancement of 5B for neurol. conditions that may benefit from sustained mitofusin activation. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Quality Control of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts