Clive, Derrick L. J.; Peng, Jianbiao; Fletcher, Stephen P.; Ziffle, Vincent E.; Wingert, David published the artcile< Synthesis of Diverse 2,3-Dihydroindoles, 1,2,3,4-Tetrahydroquinolines, and Benzo-Fused Azepines by Formal Radical Cyclization onto Aromatic Rings>, HPLC of Formula: 6850-39-1, the main research area is dihydroindole preparation; quinoline benzotetrahydro stereoselective preparation; tetrahydrobenzoazepine preparation; iodophenol chiral amino alc coupling; aryl amino alc stereoselective preparation N protection; hydroxyalkylhydroxyphenyl carbamate stereoselective preparation iodination; hydroxyphenyliodoalkyl carbamate stereoselective preparation oxidation; iodoalkylcyclohexadienyl carbamate stereoselective preparation radical cyclization; hexahydroindole carbamate preparation rearomatization; hexahydroquinoline carbamate stereoselective preparation rearomatization; carbamate hexahydroindole stereoselective preparation Grignard.
2,3-Dihydroindoles, 1,2,3,4-tetrahydroquinolines, e.g., I, and 2,3,4,5-tetrahydrobenzo[b]azepines are available by a process that represents formal radical cyclization onto aromatic rings. Optically pure benzo-fused heterocycles are also accessible by this method. P-Iodophenols, especially those with the phenolic oxygen protected as a MOM-ether, can be coupled with amino alcs. to produce N-aryl amino alcs., which can be converted into the corresponding alkyl iodides in which the nitrogen is protected as a carbamate. These compounds give cross-conjugated ketones after removal of the phenolic protecting group and oxidation with PhI(OAc)2 in the presence of MeOH. The ketones undergo 5-, 6- or 7-exo-trigonal radical cyclization, and then exposure to acid, or sequential treatment with a Grignard reagent and then acid, effects rearomatization to produce the benzo-fused nitrogen heterocycles.
Journal of Organic Chemistry published new progress about Aromatization. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, HPLC of Formula: 6850-39-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts