Chen, Hong; Sun, Jian; Liu, Jun; Gou, Yarun; Zhang, Xin; Wu, Xiaonan; Sun, Rui; Tang, Sixue; Kan, Juan; Qian, Chunlu; Zhang, Nianfeng; Jin, Changhai published the artcile< Structural characterization and anti-inflammatory activity of alkali-soluble polysaccharides from purple sweet potato>, Reference of 3458-28-4, the main research area is purple sweet potato polysaccharide structural property antiinflammatory; Alkali-soluble polysaccharide; Anti-inflammation activity; Purple sweet potato; Structural characterization.
In this study, the structural characterization and anti-inflammation effect of dilute alkali-soluble polysaccharides from purple sweet potato were investigated. Three fractions (F-1, F-2 and F-3) were obtained by purifying crude polysaccharides on DEAE-52 cellulose column. The main fraction (F-1) was further purified on Sephadex G-200 column to afford purified alkali-soluble sweet potato polysaccharide (ASPP). The chem. structure of ASPP was analyzed by gas chromatog., Fourier transform IR spectroscopy, methylation anal. and NMR spectroscopy. Monosaccharide compositional anal. showed ASPP was composed of rhamnose, arabinose, xylose, mannose and glucose in the molar ratio of 2.8:1.9:1.0:7.6:53.3. Moreover, the backbone of ASPP was composed of 1,4-linked Glcp with side chains attached to the O-6 position. The anti-inflammation effect of ASPP was further investigated by in vitro and in vivo experiments Results showed ASPP could inhibit the levels of nitric oxide, interleukin (IL)-6, IL-1β and TNF-α but increase the production of IL-10 in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. In addition ASPP could reduce the secretion of IL-6, IL-1β and TNF-α in LPS-treated mice. Our results suggest ASPP can be developed as a novel anti-inflammation agent.
International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.
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