《Rhodium-Catalysed Asymmetric Synthesis of 4-Alkyl-4H-Chromenes》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Chang, Zhiqian; Yao, Jian; Dou, Xiaowei. Reference of 2-Hydroxyphenylboronic acid The article mentions the following:
A general method for the catalytic asym. synthesis of 4-alkyl-4H-chromenes I [R1 = Me, Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4; R2 = n-Pr, cyclopropyl, Ph, etc.; R3 = H, 6-Me, 6-Cl, 6-F, 7-F] was developed. With readily available β-alkyl-substituted enones and 2-hydroxylated arylboronic acids, a rhodium-catalyzed asym. conjugate addition/intramol. hemi-acetalization/acid-promoted dehydration sequence led to the formation of 4-alkyl-4H-chromenes in up to 99% yield and with up to >99% ee. The current study remedied the methodol. deficiency in asym. synthesis of 4-alkyl-4H-chromenes I. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Reference of 2-Hydroxyphenylboronic acid) was used in this study.
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Reference of 2-Hydroxyphenylboronic acid
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts