Canning, Peter; Bataille, Carole; Bery, Nicolas; Milhas, Sabine; Hayes, Angela; Raynaud, Florence; Miller, Ami; Rabbitts, Terry published an article in 2021. The article was titled 《Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds》, and you may find the article in Journal of Immunological Methods.SDS of cas: 7748-36-9 The information in the text is summarized as follows:
The use of intracellular antibodies as templates to derive surrogate compounds is an important objective because intracellular antibodies can be employed initially for target validation in pre-clin. assays and subsequently employed in compound library screens. LMO2 is a T cell oncogenic protein activated in the majority of T cell acute leukemias. We have used an inhibitory intracellular antibody fragment as a competitor in a small mol. library screen using competitive surface plasmon resonance (cSPR) to identify compounds that bind to LMO2. We selected four compounds that bind to LMO2 but not when the anti-LMO2 intracellular antibody fragment is bound to it. These findings further illustrate the value of intracellular antibodies in the initial stages of drug discovery campaigns and more generally antibodies, or antibody fragments, can be the starting point for chem. compound development as surrogates of the antibody combining site. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9
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