《Mechanistic insight into the azo radical-promoted dehydrogenation of heteroarene towards N-heterocycles》 was written by Bains, Amreen K.; Adhikari, Debashis. Electric Literature of C7H7BrOThis research focused ontriazine pyrimidine preparation mechanism kinetics; alc amidine hydrochloride dehydrogenation nickel catalyst. The article conveys some information:
Herein, a molecularly defined nickel catalyst, which can perform two annulation reactions under mild conditions (80°, 8 h), towards the sustainable synthesis of triazine I (R = H, 4-Me, 4-F, etc.) and pyrimidine II (R = H, 4-Me, 2-F, etc.; R1 = Me, C6H5, 4-MeC6H4, 4-FC6H4) has been reported. Mechanistically, the important role of the catalyst in promoting the dehydrogenation of heteroarenes is clearly described. The binding of the saturated heterocycle to the metal catalyst underwent a pre-equilibrium step (K = 238 at 80°), which is followed by a crucial hydrogen atom transfer. A series of kinetics experiments including Van’t Hoff, Eyring anal. and interception of pyrimidinyl radical disclosed the details of the dehydrogenation process. This ligand-driven, base metal catalytic approach is significantly different from the considerably evaluated metal-ligand cooperative bond activation strategies, which may offer an alternative dehydrogenation pathway that demands less energy.(4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO) was used in this study.
(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts