《Exploiting designed oxidase-peroxygenase mutual benefit system for asymmetric cascade reactions》 was written by Yu, Da; Wang, Jian-bo; Reetz, Manfred T.. Application of 133082-13-0 And the article was included in Journal of the American Chemical Society on April 10 ,2019. The article conveys some information:
A unique P 450 monooxygenase-peroxygenase mutual benefit system was designed as the core element in the construction of a biocatalytic cascade reaction sequence leading from 3-Ph propionic acid to (R)-Ph glycol. In this system, P 450 monooxygenase (P 450-BM3) and P 450 peroxygenase (OleTJE) not only function as catalysts for the crucial initial reactions, they also ensure an internal in situ H2O2 recycle mechanism that avoids its accumulation and thus prevents possible toxic effects. By directed evolution of P 450-BM3 as the catalyst in the enantioselective epoxidation of the styrene-intermediate, formed from 3-Ph propionic acid, and the epoxide hydrolase ANEH for final hydrolytic ring opening, (R)-Ph glycol and 9 derivatives thereof were synthesized from the resp. carboxylic acids in one-pot processes with high enantioselectivity. In the experiment, the researchers used many compounds, for example, (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Application of 133082-13-0)
(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Application of 133082-13-0
Referemce:
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