Wang, Huamin; Shi, Wenyan; Li, Yongli; Yu, Mingming; Gao, Yuan; Lei, Aiwen published the artcile< Photoinduced radical relay way toward α-CF3 ketones with low-cost trifluoromethylation reagents>, Quality Control of 10602-04-7, the main research area is alpha trifluoromethyl ketone preparation; alkyne trifluoromethanesulfonic anhydride trifluoromethylation photoinduction; triethylsilyl trifluoromethanesulfonate alkyne trifluoromethylation photoinduction.
A cost-efficient and practical approach of photoinduction of a radical relay process was disclosed for the synthesis of α-CF3 ketones ArC(O)CH2CF3 [Ar = Ph, 4-ClC6H4, 4-PhC6H4, etc.] using alkynes and low-cost trifluoromethylation reagents. It was showed that trifluoromethylation reagents such as TES-OTf, Tf2O, TMS-OTf, TBS-OTf, H-OTf, and others could be used successfully as inexpensive CF3 precursors under metal-free and redox-neutral conditions. The potential application of this protocol was highlighted and gram-scale synthesis. Mechanistic studies revealed that this transformation might involve a radical process, and acetic acid not only promoted the formation of enol triflates, but also accelerated the in situ conversion from enol triflates to α-CF3 ketones.
CCS Chemistry published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Quality Control of 10602-04-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts