In 2019,Asian Journal of Chemistry included an article by Tripathi, Vishwa Deepak; Shukla, Akhilesh Kumar; Mohammed, Hasan Shamran. Application of 100-83-4. The article was titled 《Regioselective three component domino synthesis of polyhydrospiro[indoline-3,3′-pyrrolizine]-2-one via [3+2] cycloaddition reaction》. The information in the text is summarized as follows:
The synthesis and characterization of novel hexahydrospiro[indoline-3,3′-pyrrolizine]-2-one derivatives in good to excellent yields via [3+2] cycloaddtion reaction in regioselective manner was reported. These compounds were synthesized via multicomponent reaction of substituted 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-one, isatin, L-proline at room temperature All the synthesized hexahydrospiro mols. were characterized by 1H and 13C NMR, IR spectra, mass spectra and elemental anal. Regioselectivity in synthesized mols. were also explained on the basis of secondary orbital interactions. A simple and facile methodol. was developed which has great importance in synthetic chem. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4) was used in this study.
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4
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