SDS of cas: 6346-09-4On June 5, 2020, Tripathi, Shashank; Ambule, Mayur D.; Srivastava, Ajay Kumar published an article in Journal of Organic Chemistry. The article was 《Construction of Highly Functionalized Piperazinones via Post-Ugi Cyclization and Diastereoselective Nucleophilic Addition》. The article mentions the following:
Aminals were prepared by Ugi multicomponent cyclocondensation reactions of 2-aminoacetaldehyde di-Me acetal, aldehydes or ketones such as 3-indolecarboxaldehyde, carboxylic acids such as benzoic acid, and isocyanides such as benzyl isocyanide. In the presence of BF3·Et2O in CH2Cl2, the aminals underwent (diastereoselective) substitution reactions with nucleophiles such as Me3SiR [R = H2C:CHCH2, NC, N3, OCPh(:CH2)], triethylsilane, or N-methylindole to yield piperazinones such as I (X = Y = O). Ugi reactions with aminoaldehyde acetals with longer carbon chains yielded only acyclic products. I (X = Y = H2) was prepared as a dragmacidin C analog, while two piperazinones were used to prepare praziquantel analogs. The results came from multiple reactions, including the reaction of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4SDS of cas: 6346-09-4)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.SDS of cas: 6346-09-4
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