Tironi, Matteo; Hopkinson, Matthew N. published the artcile< Silver-Catalyzed Nucleophilic Deoxydifluoromethylthiolation of Activated Aliphatic Alcohols with BT-SCF2H>, Related Products of 10602-04-7, the main research area is difluoromethylthioether preparation; aliphatic alc difluoromethyl thio methylbenzothiazolium triflate nucleophilic deoxydifluoromethylthiolation silver.
Deoxygenative conversion of alcs. into difluoromethylthioethers is reported using 2-((difluoromethyl)thio)-3-methylbenzo[d]thiazol-3-ium triflate (BT-SCF2H) as a source of -SCF2H anions. The presence of silver(I) triflate as a catalyst was found to be crucial for stabilizing the in situ-generated anion, while the concomitant formation of a reactive 2-(alkoxy)benzothiazolium electrophile likely ensures a fast onward substitution reaction, avoiding the build-up of -SCF2H. To the best of authors’ knowledge, this process represents the first report of a direct nucleophilic substitution reaction with -SCF2H and delivers products containing the medicinally relevant difluoromethylthio motif in a single step from widely available alcs.
European Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Related Products of 10602-04-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts