The author of 《Metabolomics as read-across tool: An example with 3-aminopropanol and 2-aminoethanol》 were Sperber, S.; Wahl, M.; Berger, F.; Kamp, H.; Lemke, O.; Starck, V.; Walk, T.; Spitzer, M.; Van Ravenzwaay, B.. And the article was published in Regulatory Toxicology and Pharmacology in 2019. Synthetic Route of C3H9NO The author mentioned the following in the article:
Read-across and grouping is one of the most commonly used alternative approaches for data gap filling in registrations submitted under the REACH Regulation as defined by the European Chems. Agency (ECHA) in their Read-Across Assessment Framework (RAAF, 2017). At the same time, the application of read-across is rejected by ECHA frequently due to various reasons. As a major reason hereof, applicants fail to reduce the level of remaining uncertainty intrinsical to every read-across approach compared to testing a substance exptl. Recently, the use of metabolomics to support read-across cases with biol. information has been reported in a case study with phenoxy herbicides (Ravenzwaay et al., 2016). In the present case-study a weight-of-evidence read-across approach from 2-aminoethanol (MEA = source) to 3-aminopropanol (3AP = target) with metabolomics as supporting evidence reducing the remaining uncertainties is reported. We demonstrate the high structural similarity of the two analogous substances based on the available data and we report how metabolome data add confidence concerning mechanistic similarity in this read-across approach. Finally, the herein described read-across case supported by metabolomics is used to cover the data gaps in repeated dose and reproductive toxicity endpoint of 3AP via weight of evidence for the REACH-registration. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Synthetic Route of C3H9NO)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C3H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts