The author of 《Synthesis and evaluation of water-soluble 2-aryl-1-sulfonylpyrrolidine derivatives as bacterial biofilm formation inhibitors》 were Smolobochkin, Andrey V.; Muravyeva, Ekaterina A.; Vagapova, Liliya I.; Knyazeva, Irina R.; Voronina, Julia K.; Burilov, Alexander R.; Pudovik, Michail A.; Gildebrant, Anastasiya V.; Sazykin, Ivan S.; Sazykina, Marina A.; Gazizov, Almir S.. And the article was published in Chemistry & Biodiversity in 2019. Safety of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:
The approach to the novel 1-[(2-aminoethyl)sulfonyl]-2-arylpyrrolidines via unique intramol. cyclization/aza-Michael reactions of N-(4,4-diethoxybutyl)ethenesulfonamide have been developed, which benefits from high yields of target compounds, mild reaction conditions, usage of inexpensive and low-toxic reagents, and allows for wide variability in both amine and aryl moieties. Biotesting with whole-cell luminescent bacterial biosensors responding to DNA damage showed that all tested compounds are not genotoxic. Tested compounds differently affect the formation of biofilms by Vibrio aquamarinus DSM 26054. Some of the tested compounds were found to suppress the bacterial biofilms growth and thus are promising candidates for further studies.4,4-Diethoxybutan-1-amine(cas: 6346-09-4Safety of 4,4-Diethoxybutan-1-amine) was used in this study.
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 4,4-Diethoxybutan-1-amine
Referemce:
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