Slominski, R. M.; Raman, C.; Elmets, C.; Jetten, A. M.; Slominski, A. T.; Tuckey, R. C. published the artcile< The significance of CYP11A1 expression in skin physiology and pathology>, SDS of cas: 434-16-2, the main research area is review CYP11A1 IL1 IL6 TNF alpha skin physiol pathol; CYP11A1; Corticosteroid biosynthesis; Hypothalamo-pituitaryadrenal axis; Lumisterol; Neuroendocrine functions of the skin; Secosteroids; Skin; Skin barrier function; Skin immune activity; Steroids.
A review. CYP11A1, a member of the cytochrome P 450 family, plays several key roles in the human body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to pregnenolone. Aside from the classical steroidogenic tissues such as the adrenals, gonads and placenta, CYP11A1 has also been found in the brain, gastrointestinal tract, immune systems, and finally the skin. CYP11A1 activity in the skin is regulated predominately by StAR protein and hence cholesterol levels in the mitochondria. However, UVB, UVC, CRH, ACTH, cAMP, and cytokines IL-1, IL-6 and TNFα can also regulate its expression and activity. Indeed, CYP11A1 plays several critical roles in the skin through its initiation of local steroidogenesis and specific metabolism of vitamin D, lumisterol, and 7-dehydrocholesterol. Products of these pathways regulate the protective barrier and skin immune functions in a context-dependent fashion through interactions with a number of receptors. Disturbances in CYP11A1 activity can lead to skin pathol.
Molecular and Cellular Endocrinology published new progress about Animal gene, CYP11A1 Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts