Sai, Masahiro published the artcile< Direct Synthesis of Indanes via Iron-Catalyzed Dehydrative Coupling/Friedel-Crafts Cyclization of Two Different Alcohols>, Safety of Triphenylmethanol, the main research area is iron catalyzed cascade dehydrative coupling Friedel Crafts alc; indane synthesis atom economic green.
We report herein a novel iron-catalyzed cascade dehydrative coupling/Friedel-Crafts cyclization of two different alcs., providing a variety of indanes, which are ubiquitous substructures found in natural products, pharmaceuticals, and functional materials. Importantly, the developed approach is highly atom-economic and environmentally benign, as it employs readily available alcs. as substrates and generates water as the only byproduct. Thus, e.g., benzhydrol + t-BuOH → 1,1-dimethyl-3-phenylindan (82%) employing Fe(OTf)3 and PhCF3 as solvent at 105°.
European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts