In 2022,Rajput, Shruti; Kaur, Ramandeep; Jain, Nidhi published an article in Organic & Biomolecular Chemistry. The title of the article was 《Pd and photoredox dual catalysis assisted decarboxylative ortho-benzoylation of N-phenyl-7-azaindoles》.Application of 7748-36-9 The author mentioned the following in the article:
The directing group assisted decarboxylative ortho-benzoylation of N-aryl-7-azaindoles with α-keto acids was achieved by synergistic visible light promoted photoredox and palladium catalysis. The approach tenders rapid entry to aryl ketone architectures from simple α-keto acid precursors via the in situ generation of a benzoyl radical intermediate. The transformation provided a range of ortho-benzoylated N-aryl-7-azaindoles, with excellent site-selectivity and good functional group compatibility under mild reaction conditions. Biol. target predictions indicate that these mols. may serve as potential anti-cancer and anti-viral agents. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9) was used in this study.
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9
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