《Palladium-Catalyzed Barluenga-Valdes Type Cross-Coupling Reaction: Alkenylation of 7-Azaindoles》 was written by Raina, Gaurav; Kannaboina, Prakash; Ahmed, Qazi Naveed; Mondal, Krishanu; Das, Parthasarathi. Name: Oxetan-3-olThis research focused onvinyl azaindole preparation chemoselective; sulfonylhydrazone azaindole Barluenga Valdes cross coupling alkenylation palladium catalyst. The article conveys some information:
An efficient coupling method between sulfonylhydrazones ArC(CH3)=NNHTs (Ar = 3-nitrophenyl, pyridin-4-yl, naphthalen-2-yl, etc.) and 7-azaindoles I (R1 = H, 5-Br; R2 = H, I; R3 = Me, Bn, 4-methoxyphenyl) using Pd(OAc)2 as catalyst and dppf as ligand providing flexible and convergent access to different vinyl 7-azaindoles II and III is achieved. A wide variety of olefins II were obtained up to 86% yields via the coupling of numerous electronically distinct hydrazones with different 7-azaindoles I under the present catalytic conditions. The protocol was further extended to other heteroarenes such as indoles, quinolines, isoquinolines, and pyridine. The imperative feature of these protocols is its ease at the gram scale and their potential to get transformed into different valuable constructs. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol
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