Podunavac, Masa; Mailyan, Artur K.; Jackson, Jeffrey J.; Lovy, Alenka; Farias, Paula; Huerta, Hernan; Molgo, Jordi; Cardenas, Cesar; Zakarian, Armen published the artcile< Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival>, Synthetic Route of 627-27-0, the main research area is desmethylxestospongin B preparation anticancer calcium signaling mitochondrial metabolism; IP3R receptor; cancer; metabolism; total synthesis; xestospongins.
The scalable synthesis of the oxaquinolizidine marine natural product desmethylxestospongin B, I, is based on the early application of Ireland-Claisen rearrangement, macrolactamization, and a late-stage installation of the oxaquinolizidine units by lactam reduction The synthesis serves as the source of material to investigate calcium signaling and its effect on mitochondrial metabolism in various cell types, including cancer cells.
Angewandte Chemie, International Edition published new progress about Antitumor agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts