Mishra, Sanket J.; Liu, Weiya; Beebe, Kristin; Banerjee, Monimoy; Kent, Caitlin N.; Munthali, Vitumbiko; Koren, John III; Taylor, John A. III; Neckers, Leonard M.; Holzbeierlein, Jeffrey; Blagg, Brian S. J. published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition》.Related Products of 27489-62-9 The article contains the following contents:
The 90 kD heat shock proteins (Hsp90) are mol. chaperones that are responsible for the folding of select proteins, many of which are directly associated with cancer progression. Consequently, inhibition of the Hsp90 protein folding machinery results in a combinatorial attack on numerous oncogenic pathways. Seventeen small-mol. inhibitors of Hsp90 have entered clin. trials for the treatment of cancer, all of which bind the Hsp90 N-terminus and exhibit pan-inhibitory activity against all four Hsp90 isoforms, which may lead to adverse effects. The development of Hsp90 isoform-selective inhibitors represents an alternative approach toward the treatment of cancer and may limit some of these detriments. Described herein, is a structure-based approach to develop isoform-selective inhibitors of Hsp90β, which induces the degradation of select Hsp90 clients without concomitant induction of Hsp90 levels. Together, these initial studies support the development of Hsp90β-selective inhibitors as a method for overcoming the detriments associated with pan-inhibition. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Related Products of 27489-62-9
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