Meng, Zhiyuan; Tian, Sinuo; Sun, Wei; Liu, Li; Yan, Sen; Huang, Shiran; Zhu, Wentao; Zhou, Zhiqiang published the artcile< Effects of exposure to prothioconazole and its metabolite prothioconazole-desthio on oxidative stress and metabolic profiles of liver and kidney tissues in male mice>, Related Products of 492-62-6, the main research area is prothioonazole fungiide metabolic disorder oxidative stress kidney; Metabolic profile; Oxidative stress; Prothioconazole; Prothioconazole-desthio.
Prothioconazole (PTC), a popular agricultural fungicide, and its main metabolite prothioconazole-desthio (PTCd) are receiving great attention due to their toxicol. effects in the non-target organisms. This study investigated their dosage-dependent (1 and 5 mg/kg BW/day) toxicol. effects on oxidative stress and metabolic profiles of liver and kidney tissues using male mice. PTC and PTCd significantly inhibited the growth phenotype including body weights gain, liver and kidney indexes. Furthermore, these effects were deeply investigated using the biomarkers of oxidative stress, and metabolomics. Notably, these effects were dose and tissue-dependent. Specifically, the more serious impacts involving oxidative stress and metabolic disorders were observed in the high concentration treatment groups. Also, the liver tissue was more severely affected than the kidney tissue. Lastly, the change in oxidative stress biomarkers and metabolomics profile revealed that PTCd induced more severe toxic effects than the parent compound PTC. In brief, these results indicate that exposure to PTC and PTCd could cause potential health risks in mammals.
Environmental Pollution (Oxford, United Kingdom) published new progress about Biomarkers. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 492-62-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts