Manenti, Marco; Gazzotti, Stefano; Lo Presti, Leonardo; Molteni, Giorgio; Silvani, Alessandra published an article in 2021. The article was titled 《Highly diastereoselective entry to chiral oxindole-based β-amino boronic acids and spiro derivatives》, and you may find the article in Organic & Biomolecular Chemistry.Recommanded Product: 78782-17-9 The information in the text is summarized as follows:
The first Cu-catalyzed, diastereoselective 1,2-addition of bis[(pinacolato)boryl]methane to chiral ketimines I (R = Me, allyl, Bn, triphenylmethyl; R1 = H, Br, CF3; R2 = H, OMe, Cl; R3 = H, Me; R4 = H, Cl) for the synthesis of quaternary stereocenters II (R5 = dihydroxyboranyl, tetramethyl-1,3,2-dioxaborolan-2-yl) and spiro compds III and IV (X = O, NH) was described here. The method provides easy access to a range of chiral, highly functionalized compounds, namely oxindole-based β,β’-disubstituted β-amino boronates V, boron-containing peptidomimetics VI and six-, seven-membered spirocyclic hemiboronic esters III and IV. Such unprecedented compounds are mostly obtained in high yields and easily isolated as single diastereoisomers, paving the way to a more intense exploitation of boron-containing compounds in diversity-oriented chem. and drug-discovery programs. Concerning stereochem., the application of Ellman’s auxiliary strategy allows in principle to access both steric series of target compounds The experimental part of the paper was very detailed, including the reaction process of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: 78782-17-9)
Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.Recommanded Product: 78782-17-9
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