In 2022,Logvinenko, Ivan G.; Kondratov, Ivan S.; Pridma, Stanislav O.; Tolmachova, Nataliya A.; Morev, Roman N.; Dolovanyuk, Violetta G.; Boretskyi, Andrii L.; Stepaniuk, Roman O.; Trofymchuk, Serhii A.; Muck-Lichtenfeld, Christian; Daniliuc, Constantin G.; Haufe, Gunter published an article in Journal of Fluorine Chemistry. The title of the article was 《Synthesis and physical chemical properties of CF3O-containing secondary amines-Perspective building blocks for drug discovery》.HPLC of Formula: 18621-18-6 The author mentioned the following in the article:
Conformational and electronic effects of the trifluoromethoxy group make it attractive to be introduced in biorelevant structures. A mini-library of CF3O-substituted piperidines, pyrrolidines and azetidines was synthesized in 4-5 steps from com. amino alcs. Comparison of the measured pKa- and log D7.4 values of selected regioisomeric CF3O piperidines with the corresponding CF3- and MeO analogs shows that the effect on the acid/base properties and lipophilicity is rather complex and depends of the substitution position and the conformation of the mols. For the most stable conformers of β-OCF3 compounds 2-(trifluoromethoxymethyl)piperidine and 3-trifloromethoxypiperidine, DFT calculations and X-ray data for 2-(trifluoromethoxymethyl)piperidine show a favored gauche-arrangement with regard to the amino group. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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