SDS of cas: 4048-33-3In 2020 ,《Protein and mRNA Delivery Enabled by Cholesteryl-Based Biodegradable Lipidoid Nanoparticles》 appeared in Angewandte Chemie, International Edition. The author of the article were Li, Yamin; Jarvis, Rachel; Zhu, Kuixin; Glass, Zachary; Ogurlu, Roza; Gao, Peiyang; Li, Peixuan; Chen, Jinjin; Yu, Yingjie; Yang, Yongjie; Xu, Qiaobing. The article conveys some information:
Developing safe and efficient delivery systems for therapeutic biomacromols. is a long-standing challenge. Herein, we report a newly developed combinatorial library of cholesteryl-based disulfide bond-containing biodegradable cationic lipidoid nanoparticles. We have identified a subset of this library which is effective for protein and mRNA delivery in vitro and in vivo. These lipidoids showed comparable transfection efficacies but much lower cytotoxicities compared to the Lpf2k in vitro. In vivo studies in adult mice demonstrated the successful delivery of genome engineering protein and mRNA mols. in the skeletal muscle (via i.m. injection), lung and spleen (via i.v. injection), and brain (via lateral ventricle infusion). The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)
6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.SDS of cas: 4048-33-3
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