Li, Tingna; Zeng, Hairong; Zeng, Yijia; Zhang, Xiaorui; Ren, Yuanyuan; Gao, Yongxiang; Huang, Qinwan; Tan, Jin published the artcile< Characterization of the bioactive compounds with efficacy against gout in Guizhi Shaoyao Zhimu Decoction by UHPLC-Q-Orbitrap HRMS combined with network pharmacological analysis>, Application In Synthesis of 87-73-0, the main research area is Guizhi Shaoyao Zhimu decoction antiarthritic agent gouty arthritis.
The current study aimed to explore the mechanism of Guizhi Shaoyao Zhimu Decoction in the treatment of gouty arthritis based on the combination of Vanquish Ultra High Performance Liquid Chromatog. Q Exactive IV Pole-electrostatic field orbital trap high resolution mass spectrometer (UHPLC-Q-Orbitrap HRMS) and network pharmacol. Firstly, UHPLC-Q-Orbitrap HRMS was established and applied to separation and identification of the chem. components of GSZD. Then, using network pharmacol. anal. to obtain the potential active components and candidate targets underlying the effect of GSZD on gouty arthritis (GA). Through targeted and untargeted anal., a total of 79 components, including 3 chromones, 26 flavonoids, 10 alkaloids, 10 phenolic acids, 7 nucleosides and nucleobases, and 23 other components, were characterized from GSZD. 11 compounds were considered to potentially key active compounds against GA which may be via interacting with multiple inflammatory factors and multiple inflammatory pathways.
Arabian Journal of Chemistry published new progress about Activator protein 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts