《N-Heterocyclic Carbene-Catalyzed Activation of Ynals for the Construction of Functional Pyridines》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Li, Jia-Hui; Duan, Xiao-Yong; Tian, Zhao-Hui; Zheng, Yi-Fan; Qi, Jing. Electric Literature of C9H11NO The article mentions the following:
N-heterocyclic carbene-catalyzed activation of ynals for rapid synthesis of pyridine derivatives with important utilities was reported. This successful strategy using NHC-bound alkynyl acyl azolium as the key intermediate further improved the application of N-Ts 2-aminoacrylate as a nucleophile. Importantly, this work introduced an ester substituent to pyridines that was easily transformed to other functional groups.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Electric Literature of C9H11NO) was used in this study.
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Electric Literature of C9H11NO
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