Reference of trans-4-AminocyclohexanolIn 2017 ,《Synthesis of 4-Heteroaryl-Quinazoline Derivatives as Potential Anti-breast Cancer Agents》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Kassab, A. E.; Gedawy, E. M.; El-Nassan, H. B.. The article conveys some information:
The 4-heteroaryl or heteroalkyl-quinazoline derivatives e.g., I were prepared as dual epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. These compounds were tested for their dual enzyme inhibition as well as their cytotoxic activity on MCF7 cell line. The results indicated that almost all the compounds showed moderate dual inhibition of both enzymes. The compound methyl1-(6,7-dimethoxyquinazolin-4-yl)piperidine-4-carboxylate showed the highest inhibitory activity against both enzymes with IC50 97.6 and 64.0 μM against EGFR and VEGFR-2 kinases, resp. Most of the test compounds showed potent to moderate antitumor activity on MCF7 cell line. Some of the compounds showed potent cytotoxic activity with IC50 values between 10 and 17 M. The results came from multiple reactions, including the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Reference of trans-4-Aminocyclohexanol)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of trans-4-Aminocyclohexanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts