Kashiwadani, Hideki; Higa, Yurina; Sugimura, Mitsutaka; Kuwaki, Tomoyuki published the artcile< Linalool odor-induced analgesia is triggered by transient receptor potential ankyrin 1-independent pathway in mice>, Electric Literature of 78-70-6, the main research area is linalool odor analgesia transient receptor potential ankyrin 1; Analgesia; Linalool; TRPA1; TRPA1-deficient mice; TRPA1-selective antagonist.
Abstract: We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemial senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute toward triggering the linalool odor-induced analgesia, still remain unexplored. In vitro studies have shown that the transient receptor potential ankyrin 1 (TRPA1) responded to linalool, thus raising the possibility that TRPA1 expressed on the trigeminal nerve terminal detects linalool odor inhaled into the nostril and triggers the analgesic effects. To address this hypothesis, we measured the behavioral pain threshold for noxious mech. stimulation in TRPA1-deficient mice. In contrast to our expectation, we found a significant increase in the threshold after linalool odor exposure in TRPA1-deficient mice, indicating the analgesic effects of linalool odor even in TRPA1-deficient mice. Furthermore, intranasal application of TRPA1 selective antagonist did not alter the analgesic effect of linalool odor. These results showed that the linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.
Behavioral and Brain Functions published new progress about Analgesia. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.
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