Kai, Hiroyuki; Morioka, Yasuhide; Tomida, Minoru; Takahashi, Tadashi; Hattori, Maki; Hanasaki, Kohji; Koike, Katsumi; Chiba, Hiroki; Shinohara, Shunji; Kanemasa, Toshiyuki; Iwamoto, Yuka; Takahashi, Kohji; Yamaguchi, Yoshitaka; Baba, Takahiko; Yoshikawa, Takayoshi; Takenaka, Hideyuki published the artcile< 2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: Orally bioavailable compounds>, Recommanded Product: (1-(Aminomethyl)cyclopropyl)methanol, the main research area is cannabinoid receptor analgesia oral bioavailability thiazine derivative SAR.
Structure-activity relationships and efforts to optimize the pharmacokinetic profile of a class of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among the compounds examined, compound 14 showed potent affinity and high selectivity for CB2, and compound 23 showed potent affinities against CB1 and CB2. These compounds displayed oral bioavailability.
Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, Recommanded Product: (1-(Aminomethyl)cyclopropyl)methanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts