Hoseini, Asma; Namazi, Gholamreza; Farrokhian, Alireza; Reiner, Zeljko; Aghadavod, Esmat; Bahmani, Fereshteh; Asemi, Zatollah published the artcile< The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease>, Application of C14H12O3, the main research area is diet supplement diabetes mellitus coronary heart disease resveratrol.
This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed with 56 patients having T2DM and CHD. The patients were randomly divided into two groups to receive either 500 mg resveratrol per day (n = 28) or placebo (n = 28) for 4 wk. Resveratrol reduced fasting glucose (β-10.04 mg dL-1; 95% CI, -18.23, -1.86; P = 0.01), insulin (β -1.09μIU mL-1; 95% CI, -1.93, -0.24; P = 0.01) and insulin resistance (β -0.48; 95% CI, -0.76, -0.21; P = 0.001) and significantly increased insulin sensitivity (β 0.006; 95% CI, 0.001, 0.01; P = 0.02) when compared with the placebo. Resveratrol also significantly increased HDL-cholesterol levels (β 3.38 mg dL-1; 95% CI, 1.72, 5.05; P < 0.001) and significantly decreased the total-/HDL-cholesterol ratio (β-0.36; 95% CI, -0.59, -0.13; P = 0.002) when compared with the placebo. Addnl., resveratrol caused a significant increase in total antioxidant capacity (TAC) (β 58.88 mmol L-1; 95% CI, 17.33, 100.44; P = 0.006) and a significant reduction in malondialdehyde (MDA) levels (β -0.21μmol L-1; 95% CI, -0.41, -0.005; P = 0.04) when compared with the placebo. Resveratrol upregulated PPAR-γ (P = 0.01) and sirtuin 1 (SIRT1) (P = 0.01) in the peripheral blood mononuclear cells (PBMCs) of T2DM patients with CHD. Resveratrol supplementation did not have any effect on inflammatory markers. Four-week supplementation of resveratrol in patients with T2DM and CHD had beneficial effects on glycemic control, HDL-cholesterol levels, the total-/HDL-cholesterol ratio, TAC and MDA levels. Resveratrol also upregulated PPAR-γ and SIRT1 in the PBMCs of T2DM patients with CHD. Food & Function published new progress about Acetylation. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts