Formula: C3H9NO2In 2020 ,《PH-responsive artesunate polymer prodrugs with enhanced ablation effect on rodent xenograft colon cancer》 was published in International Journal of Nanomedicine. The article was written by Hao, Dan-Li; Xie, Ran; De, Ge-Jing; Yi, Hong; Zang, Chen; Yang, Mi-Yi; Liu, Li; Ma, Hai; Cai, Wei-Yan; Zhao, Qing-He; Sui, Feng; Chen, Yan-Jun. The article contains the following contents:
Purpose: In this study, pH-sensitive poly(2-ethyl-2-oxazoline)-poly(lactic acid)-poly(β-amino ester) (PEOz-PLA-PBAE) triblock copolymers were synthesized and were conjugated with an antimalaria drug artesunate (ART), for inhibition of a colon cancer xenograft model. The as-prepared polymer prodrugs are tended to self-assemble into polymeric micelles in aqueous milieu, with PEOz segment as hydrophilic shell and PLA-PBAE segment as hydrophobic core. The pH sensitivity of the as-prepared copolymers was confirmed by acid-base titration with pKb values around 6.5. The drug-conjugated polymer micelles showed high stability for at least 96 h in PBS and 37°C, resp. The as-preparation copolymer prodrugs showed high drug loading content, with 9.57% ±1.24% of drug loading for PEOz-PLA-PBAE-ART4. The conjugated ART could be released in a sustained and pH-dependent manner, with 92% of released drug at pH 6.0 and 57% of drug released at pH 7.4, resp. In addition, in vitro experiments showed higher inhibitory effect of the prodrugs on rodent CT-26 cells than that of free ART. Animal studies also demonstrated the enhanced inhibitory efficacy of PEOz-PLA-PBAE-ART2 micelles on the growth of rodent xenograft tumor. The pH-responsive artesunate polymer prodrugs are promising candidates for colon cancer adjuvant therapy. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C3H9NO2
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