Han, Ming-Liang; Chen, Jun-Jie; Xu, Hui; Huang, Zhi-Cong; Huang, Wei; Liu, Yu-Wen; Wang, Xing; Liu, Min; Guo, Zi-Qiong; Dai, Hui-Xiong published the artcile< Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters>, Category: alcohols-buliding-blocks, the main research area is aryl thioester nucleophile haloalkane palladium norbornene catalyst decarbonylaive Catellani; alkyl nucleophilic arene preparation.
Herein, a novel decarbonylative Catellani reaction via palladium-catalyzed, norbornene (NBE)-mediated polyfunctionalization of aromatic thioesters, which served as readily available carboxylic acid derivs was reported. A variety of alkenyl, alkyl, aryl and sulfur moieties was conveniently introduced into the ipso-positions of the aromatic thioesters. By combining carboxyl-directed C-H functionalization and the classical Catellani reaction, this protocol allows for the construction of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted arenes from simple aromatic acids. Furthermore, the late-stage functionalization of a series of drug mols. highlights the potential utility of the reaction.
JACS Au published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts